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AP Biology · Unit 1: Chemistry of Life

1.2 Elements of Life

A few elements build everything

Just six elements make up about 96% of living matter: carbon (C), hydrogen (H), nitrogen (N), oxygen (O), phosphorus (P), and sulfur (S) — remember them as CHNOPS. Oxygen, carbon, hydrogen, and nitrogen alone account for most of your mass.

Carbon is the backbone

Carbon has 4 valence electrons, so it forms four covalent bonds. That lets it build long chains, branches, and rings — the skeletons of nearly every organic molecule. This bonding versatility is why life's molecules are so diverse.

Trace elements still matter

Some elements are needed only in tiny amounts — trace elements — but are still essential. Iron is needed to carry oxygen in hemoglobin; iodine for thyroid hormones. Phosphorus is central to nucleic acids, ATP, and phospholipids; nitrogen is found in proteins and nucleic acids; sulfur appears in some amino acids.

Key terms

CHNOPS
Carbon, Hydrogen, Nitrogen, Oxygen, Phosphorus, Sulfur — the six main elements of life.
Valence electrons
Outer-shell electrons that determine bonding. Carbon has 4, so it forms 4 bonds.
Organic molecule
A carbon-based molecule, typically containing C–H bonds.
Trace element
An element needed in very small amounts but still essential (e.g., iron, iodine).
Role of phosphorus
Backbone of nucleic acids, the energy-carrying part of ATP, and the heads of phospholipids.

Try an AP-style question

Experiment

Researchers grow bacteria in a medium where the only nitrogen source contains the heavy isotope ¹⁵N. After several generations, the cells are broken open and fractionated.

Which cellular molecules would contain the ¹⁵N label?

  1. Carbohydrates and lipids
  2. Only phospholipids and ATP
  3. Only nucleic acids
  4. Proteins and nucleic acids
Show the answer

D. Nitrogen is found in amino acids (amine groups) and nucleotide bases. Typical carbohydrates and fatty acids contain no nitrogen.

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